So, that's probably minor. The next bit is not. Nuendo can't export audio. By that, I mean that export->audio file doesn't work. You get the file/format browser, then when you select "okay," no matter what format, it just goes back to normal operation without rendering anything. I haven't been able to find any information on this particular issue, so I just nutted up and bought Cubase 4. Yes, I'm the sort of person that buys a new car when the old one gets a flat tire, apparently.
Long story short, you'll get a Crandall-flavored review of Cubase 4 in a few days.
MEA CULPA: I'm a retard. There was one checkbox which is usually ticked which wasn't. Nuendo renders fine in Vista. So ignore basically everything I just wrote. However, Cubase 4 is still ordered.